EIF1

eukaryotic translation initiation factor 1 | A121, EIF-1, EIF1A, ISO1, SUI1

Enables ribosomal small subunit binding activity and translation initiation factor activity. Involved in regulation of translational initiation and translational initiation. Located in cytoplasm and nucleus. Part of eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; and multi-eIF complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1

Biological processes 24 terms

RNA binding (GO:0003723)RNA binding (GO:0003723)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)eukaryotic 43S preinitiation complex (GO:0016282)eukaryotic 43S preinitiation complex (GO:0016282)eukaryotic 48S preinitiation complex (GO:0033290)multi-eIF complex (GO:0043614)nucleus (GO:0005634)protein binding (GO:0005515)regulation of gene expression (GO:0010468)regulation of translational initiation (GO:0006446)regulation of translational initiation (GO:0006446)ribosomal small subunit binding (GO:0043024)ribosomal small subunit binding (GO:0043024)translation factor activity, RNA binding (GO:0008135)translation initiation factor activity (GO:0003743)translation initiation factor activity (GO:0003743)translation initiation factor activity (GO:0003743)translation initiation factor activity (GO:0003743)translation initiation factor activity (GO:0003743)translational initiation (GO:0006413)translational initiation (GO:0006413)

Expression (TPM)

TFs regulating EIF1 0 TFs

Transcription factors with Perturb-seq knockdown data for EIF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to EIF1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:40,417,289–40,418,494	1270.8 kb	Distal (>10kb) Multiome HiCAR	793
chr17:40,615,478–40,615,916	1073.2 kb	Distal (>10kb) Multiome HiCAR	297
chr17:41,527,111–41,529,407	160.5 kb	Distal (>10kb) Multiome	635
chr17:41,529,883–41,531,145	158.4 kb	Distal (>10kb) Multiome	504
chr17:41,548,740–41,549,518	139.7 kb	Distal (>10kb) Multiome	698
chr17:41,579,549–41,580,064	109.2 kb	Distal (>10kb) Multiome	335
chr17:41,647,765–41,648,495	40.8 kb	Distal (>10kb) Multiome	519
chr17:41,662,549–41,663,015	26.0 kb	Distal (>10kb) Multiome	643
chr17:41,665,564–41,667,291	21.7 kb	Distal (>10kb) Multiome	883
chr17:41,688,103–41,690,064	47 bp	At TSS Multiome	1236
chr17:41,733,761–41,735,187	45.8 kb	Distal (>10kb) Multiome	577
chr17:41,738,054–41,738,690	49.3 kb	Distal (>10kb) Multiome	596
chr17:41,784,980–41,787,229	97.9 kb	Distal (>10kb) Multiome	958
chr17:41,793,527–41,794,326	105.0 kb	Distal (>10kb) Multiome	597
chr17:41,800,647–41,802,040	113.0 kb	Distal (>10kb) Multiome	766
chr17:41,811,252–41,813,275	124.1 kb	Distal (>10kb) Multiome	997
chr17:41,835,756–41,836,400	147.3 kb	Distal (>10kb) Multiome	568
chr17:41,864,608–41,865,695	176.6 kb	Distal (>10kb) Multiome	913
chr17:41,913,670–41,914,569	225.2 kb	Distal (>10kb) Multiome	190
chr17:41,918,026–41,919,794	230.3 kb	Distal (>10kb) Multiome	956
chr17:41,930,220–41,930,908	241.6 kb	Distal (>10kb) Multiome	915
chr17:41,965,771–41,967,327	277.9 kb	Distal (>10kb) Multiome	920

Genome Browser

Genomic view of the EIF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.