Enables SMAD binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and transforming growth factor beta receptor complex assembly. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EID2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EID2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EID2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:39,307,021–39,308,955 | 232.7 kb | Distal (>10kb) Multiome | 358 | |
| chr19:39,320,514–39,321,175 | 219.3 kb | Distal (>10kb) Multiome | 364 | |
| chr19:39,341,491–39,342,890 | 197.9 kb | Distal (>10kb) Multiome | 934 | |
| chr19:39,390,544–39,391,970 | 149.0 kb | Distal (>10kb) Multiome | 1003 | |
| chr19:39,397,520–39,398,126 | 142.3 kb | Distal (>10kb) Multiome | 711 | |
| chr19:39,402,336–39,404,125 | 136.2 kb | Distal (>10kb) Multiome | 826 | |
| chr19:39,406,270–39,408,010 | 133.4 kb | Distal (>10kb) Multiome | 804 | |
| chr19:39,409,417–39,410,433 | 130.4 kb | Distal (>10kb) Multiome | 884 | |
| chr19:39,411,293–39,414,170 | 127.7 kb | Distal (>10kb) Multiome | 1109 | |
| chr19:39,428,269–39,428,993 | 111.5 kb | Distal (>10kb) Multiome | 479 | |
| chr19:39,435,526–39,436,258 | 104.1 kb | Distal (>10kb) Multiome | 930 | |
| chr19:39,445,191–39,446,019 | 94.6 kb | Distal (>10kb) Multiome | 927 | |
| chr19:39,480,241–39,481,284 | 59.4 kb | Distal (>10kb) Multiome | 880 | |
| chr19:39,497,736–39,498,430 | 42.2 kb | Distal (>10kb) Multiome | 558 | |
| chr19:39,502,647–39,503,265 | 37.2 kb | Distal (>10kb) Multiome | 835 | |
| chr19:39,506,926–39,507,691 | 32.9 kb | Distal (>10kb) Multiome | 748 | |
| chr19:39,514,761–39,515,964 | 24.9 kb | Distal (>10kb) Multiome | 370 | |
| chr19:39,532,304–39,533,247 | 7.3 kb | Proximal (<10kb) Multiome | 760 | |
| chr19:39,539,469–39,540,414 | 20 bp | At TSS Multiome | 772 | |
| chr19:39,793,033–39,793,501 | 253.1 kb | Distal (>10kb) Multiome | 418 | |
| chr19:39,824,152–39,825,056 | 284.5 kb | Distal (>10kb) Multiome | 531 | |
| chr19:39,833,207–39,834,766 | 293.7 kb | Distal (>10kb) Multiome | 779 |
Genomic view of the EID2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.