Enables histone acetyltransferase binding activity. Involved in cell differentiation and negative regulation of DNA-templated transcription. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasmic ribonucleoprotein granule and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EID1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EID1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EID1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:48,644,398–48,646,594 | 232.2 kb | Distal (>10kb) Multiome | 507 | |
| chr15:48,710,844–48,711,587 | 167.0 kb | Distal (>10kb) Multiome | 181 | |
| chr15:48,810,417–48,812,023 | 66.9 kb | Distal (>10kb) Multiome | 720 | |
| chr15:48,877,739–48,878,642 | 27 bp | At TSS Multiome | 662 | |
| chr15:48,962,833–48,964,051 | 85.5 kb | Distal (>10kb) Multiome | 430 | |
| chr15:48,975,511–48,976,786 | 97.8 kb | Distal (>10kb) Multiome | 622 | |
| chr15:49,045,768–49,047,113 | 168.4 kb | Distal (>10kb) Multiome | 979 | |
| chr15:49,154,953–49,156,105 | 277.6 kb | Distal (>10kb) Multiome | 952 | |
| chr15:49,169,904–49,170,701 | 292.1 kb | Distal (>10kb) Multiome | 762 |
Genomic view of the EID1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.