Enables peptidyl-proline 4-dioxygenase activity. Involved in protein hydroxylation. Located in cytosol and nucleus. Implicated in renal cell carcinoma. Biomarker of clear cell renal cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EGLN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EGLN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EGLN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:33,765,182–33,765,847 | 185.6 kb | Distal (>10kb) Multiome | 167 | |
| chr14:33,848,926–33,849,525 | 101.7 kb | Distal (>10kb) Multiome | 373 | |
| chr14:33,931,181–33,931,973 | at TSS | At TSS | 99 | |
| chr14:33,932,765–33,933,181 | 1.4 kb | Proximal (<10kb) | 118 | |
| chr14:33,938,191–33,938,634 | 6.9 kb | Proximal (<10kb) | 470 | |
| chr14:33,940,435–33,940,961 | 9.1 kb | Proximal (<10kb) | 92 | |
| chr14:33,949,174–33,951,931 | 4 bp | At TSS Multiome | 830 | |
| chr14:33,959,682–33,960,140 | 8.6 kb | Proximal (<10kb) | 111 | |
| chr14:34,059,777–34,060,961 | 109.2 kb | Distal (>10kb) Multiome | 774 | |
| chr14:34,331,736–34,332,458 | 381.0 kb | Distal (>10kb) Multiome | 698 | |
| chr14:34,460,930–34,461,135 | 1.6 kb | Proximal (<10kb) | 214 | |
| chr14:34,461,634–34,463,144 | 511.3 kb | Distal (>10kb) Multiome | 931 | |
| chr14:34,629,461–34,630,514 | 679.1 kb | Distal (>10kb) Multiome | 907 | |
| chr14:34,693,166–34,693,989 | 742.3 kb | Distal (>10kb) Multiome | 463 | |
| chr14:34,713,982–34,715,044 | 763.6 kb | Distal (>10kb) Multiome | 919 |
Genomic view of the EGLN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.