Predicted to enable calcium ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EFCAB10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EFCAB10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EFCAB10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:105,350,605–105,351,448 | 230.4 kb | Distal (>10kb) Multiome | 116 | |
| chr7:105,387,785–105,389,508 | 192.5 kb | Distal (>10kb) Multiome | 725 | |
| chr7:105,521,330–105,522,854 | 59.3 kb | Distal (>10kb) Multiome | 900 | |
| chr7:105,531,803–105,532,700 | 49.3 kb | Distal (>10kb) Multiome | 946 | |
| chr7:105,580,977–105,581,814 | 15 bp | At TSS Multiome | 492 | |
| chr7:105,589,529–105,589,732 | 8.0 kb | Proximal (<10kb) | 258 | |
| chr7:105,638,494–105,639,567 | 57.8 kb | Distal (>10kb) Multiome | 209 | |
| chr7:105,643,274–105,643,732 | 62.1 kb | Distal (>10kb) Multiome | 211 | |
| chr7:105,651,976–105,652,948 | 71.1 kb | Distal (>10kb) Multiome | 292 | |
| chr7:105,655,354–105,656,152 | 74.2 kb | Distal (>10kb) Multiome | 203 | |
| chr7:105,657,015–105,657,727 | 75.8 kb | Distal (>10kb) Multiome | 205 | |
| chr7:105,664,641–105,665,449 | 83.6 kb | Distal (>10kb) Multiome | 422 | |
| chr7:105,689,008–105,690,124 | 107.9 kb | Distal (>10kb) Multiome | 195 | |
| chr7:105,695,816–105,698,274 | 115.8 kb | Distal (>10kb) Multiome | 292 | |
| chr7:105,849,145–105,849,924 | 268.2 kb | Distal (>10kb) Multiome | 308 | |
| chr7:105,876,091–105,877,586 | 295.2 kb | Distal (>10kb) Multiome | 773 | |
| chr7:106,042,587–106,043,289 | 461.4 kb | Distal (>10kb) Multiome HiCAR | 430 |
Genomic view of the EFCAB10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.