Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EEF1AKMT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EEF1AKMT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EEF1AKMT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:20,525,162–20,526,319 | 248.2 kb | Distal (>10kb) Multiome | 695 | |
| chr13:20,566,412–20,567,667 | 206.9 kb | Distal (>10kb) Multiome | 901 | |
| chr13:20,703,037–20,704,890 | 69.7 kb | Distal (>10kb) Multiome | 620 | |
| chr13:20,773,202–20,774,439 | 68 bp | At TSS Multiome | 873 | |
| chr13:20,902,026–20,903,305 | 128.9 kb | Distal (>10kb) Multiome | 749 | |
| chr13:21,060,253–21,061,988 | 287.6 kb | Distal (>10kb) Multiome | 817 |
Genomic view of the EEF1AKMT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.