Transcription factors with Perturb-seq knockdown data for EDIL3-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EDIL3-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EDIL3-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:83,714,660–83,715,756 | 667.4 kb | Distal (>10kb) Multiome HiCAR | 275 | |
| chr5:84,377,151–84,377,395 | 5.0 kb | Proximal (<10kb) | 9 | |
| chr5:84,381,925–84,385,527 | 2.3 kb | Proximal (<10kb) Multiome | 606 | |
| chr5:84,480,888–84,481,719 | 98.8 kb | Distal (>10kb) Multiome | 161 |
Genomic view of the EDIL3-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.