ECSIT

ECSIT signaling integrator | SITPEC

Enables molecular adaptor activity. Involved in regulation of oxidoreductase activity; regulation of protein complex stability; and toll-like receptor 4 signaling pathway. Located in cytosol; mitochondrion; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 26 terms

cell surface receptor protein serine/threonine kinase signaling pathway (GO:0007178)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)enzyme inhibitor activity (GO:0004857)enzyme inhibitor activity (GO:0004857)innate immune response (GO:0045087)mitochondrial complex I intermediate assembly complex (GO:0160295)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial respiratory chain complex I assembly (GO:0032981)mitochondrial respiratory chain complex I assembly (GO:0032981)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)molecular adaptor activity (GO:0060090)molecular adaptor activity (GO:0060090)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein-macromolecule adaptor activity (GO:0030674)toll-like receptor 4 signaling pathway (GO:0034142)toll-like receptor 4 signaling pathway (GO:0034142)

Expression (TPM)

TFs regulating ECSIT 0 TFs

Transcription factors with Perturb-seq knockdown data for ECSIT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ECSIT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ECSIT

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ECSIT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:11,243,345–11,243,968	285.6 kb	Distal (>10kb) Multiome	448
chr19:11,262,060–11,262,653	266.7 kb	Distal (>10kb) Multiome	406
chr19:11,339,100–11,339,837	189.5 kb	Distal (>10kb) Multiome	506
chr19:11,346,053–11,346,958	182.7 kb	Distal (>10kb) Multiome	676
chr19:11,355,078–11,355,735	173.7 kb	Distal (>10kb) Multiome	382
chr19:11,361,368–11,362,625	167.5 kb	Distal (>10kb) Multiome	256
chr19:11,374,474–11,375,717	154.2 kb	Distal (>10kb) Multiome	866
chr19:11,380,761–11,382,262	147.8 kb	Distal (>10kb) Multiome	798
chr19:11,382,830–11,384,509	144.8 kb	Distal (>10kb) Multiome	761
chr19:11,418,061–11,419,498	110.5 kb	Distal (>10kb) Multiome	421
chr19:11,420,614–11,422,979	107.0 kb	Distal (>10kb) Multiome	507
chr19:11,434,817–11,436,365	93.8 kb	Distal (>10kb) Multiome	927
chr19:11,479,217–11,480,146	49.5 kb	Distal (>10kb) Multiome	394
chr19:11,481,847–11,483,040	46.5 kb	Distal (>10kb) Multiome	938
chr19:11,504,741–11,506,612	23.8 kb	Distal (>10kb) Multiome	854
chr19:11,528,581–11,529,391	34 bp	At TSS Multiome	866
chr19:11,530,487–11,530,757	1.4 kb	Proximal (<10kb)	378
chr19:11,535,847–11,536,353	7.0 kb	Proximal (<10kb) Multiome	694
chr19:11,538,464–11,539,111	9.6 kb	Proximal (<10kb) Multiome	235
chr19:11,539,738–11,540,434	10.9 kb	Distal (>10kb) Multiome	176
chr19:11,558,908–11,559,777	30.2 kb	Distal (>10kb) Multiome	686
chr19:11,597,206–11,598,107	68.3 kb	Distal (>10kb) Multiome	914
chr19:11,639,337–11,640,481	110.6 kb	Distal (>10kb) Multiome	660
chr19:11,694,497–11,695,341	165.9 kb	Distal (>10kb) Multiome	608
chr19:11,737,998–11,739,422	209.9 kb	Distal (>10kb) Multiome	704

Genome Browser

Genomic view of the ECSIT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.