Predicted to enable carboxy-lyase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ECHDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ECHDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ECHDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:125,421,627–125,422,704 | 1921.5 kb | Distal (>10kb) Multiome HiCAR | 252 | |
| chr6:127,118,017–127,121,704 | 225.0 kb | Distal (>10kb) Multiome | 622 | |
| chr6:127,266,246–127,267,883 | 76.6 kb | Distal (>10kb) Multiome | 1001 | |
| chr6:127,297,458–127,298,045 | 45.8 kb | Distal (>10kb) Multiome | 248 | |
| chr6:127,337,168–127,337,396 | 6.0 kb | Proximal (<10kb) | 6 | |
| chr6:127,342,123–127,344,593 | 158 bp | At TSS Multiome | 975 | |
| chr6:127,483,397–127,484,154 | 140.1 kb | Distal (>10kb) Multiome | 288 | |
| chr6:127,514,397–127,517,019 | 172.9 kb | Distal (>10kb) Multiome | 855 | |
| chr6:127,518,139–127,519,697 | 175.5 kb | Distal (>10kb) Multiome HiCAR | 431 |
Genomic view of the ECHDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.