Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cytosol and sperm flagellum. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DYNLT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYNLT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYNLT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:169,619,312–169,620,680 | 131.9 kb | Distal (>10kb) Multiome | 164 | |
| chr6:169,654,626–169,655,354 | 96.7 kb | Distal (>10kb) Multiome | 165 | |
| chr6:169,701,339–169,702,982 | 49.4 kb | Distal (>10kb) Multiome | 1050 | |
| chr6:169,723,431–169,725,573 | 27.0 kb | Distal (>10kb) Multiome | 1078 | |
| chr6:169,751,101–169,752,286 | 97 bp | At TSS Multiome | 1057 | |
| chr6:169,789,764–169,790,892 | 38.8 kb | Distal (>10kb) Multiome | 772 | |
| chr6:170,006,902–170,008,105 | 255.7 kb | Distal (>10kb) Multiome | 196 |
Genomic view of the DYNLT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.