This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for DYNC1I2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYNC1I2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYNC1I2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:171,433,096–171,434,895 | 253.3 kb | Distal (>10kb) Multiome | 1119 | |
| chr2:171,522,038–171,523,908 | 164.8 kb | Distal (>10kb) Multiome | 755 | |
| chr2:171,687,283–171,688,178 | 113 bp | At TSS Multiome | 886 | |
| chr2:171,893,197–171,894,662 | 206.9 kb | Distal (>10kb) Multiome | 909 | |
| chr2:171,922,015–171,923,029 | 234.9 kb | Distal (>10kb) Multiome | 901 | |
| chr2:172,101,429–172,103,305 | 415.4 kb | Distal (>10kb) Multiome HiCAR | 953 |
Genomic view of the DYNC1I2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.