Enables phosphatase activity. Involved in dephosphorylation. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DUSP28. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUSP28 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUSP28, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:240,556,853–240,557,075 | 3.7 kb | Proximal (<10kb) | 126 | |
| chr2:240,557,164–240,558,401 | 2.4 kb | Proximal (<10kb) | 226 | |
| chr2:240,560,183–240,561,566 | at TSS | At TSS | 1021 | |
| chr2:240,566,043–240,567,010 | 5.3 kb | Proximal (<10kb) | 749 | |
| chr2:240,567,779–240,569,178 | 7.0 kb | Proximal (<10kb) | 615 |
Genomic view of the DUSP28 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.