Enables protein tyrosine/serine/threonine phosphatase activity. Involved in dephosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DUSP23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUSP23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUSP23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:159,171,210–159,173,452 | 609.3 kb | Distal (>10kb) Multiome HiCAR | 251 | |
| chr1:159,187,164–159,189,000 | 592.4 kb | Distal (>10kb) Multiome HiCAR | 228 | |
| chr1:159,780,492–159,781,699 | 94 bp | At TSS Multiome | 641 | |
| chr1:159,790,392–159,790,619 | 9.4 kb | Proximal (<10kb) | 75 | |
| chr1:159,853,905–159,855,297 | 73.8 kb | Distal (>10kb) Multiome | 474 | |
| chr1:159,899,910–159,900,706 | 119.3 kb | Distal (>10kb) Multiome HiCAR | 349 | |
| chr1:159,915,918–159,916,996 | 135.5 kb | Distal (>10kb) Multiome | 465 | |
| chr1:159,922,909–159,926,224 | 144.6 kb | Distal (>10kb) Multiome | 922 | |
| chr1:159,929,315–159,930,329 | 148.7 kb | Distal (>10kb) Multiome | 235 | |
| chr1:159,936,265–159,937,075 | 155.6 kb | Distal (>10kb) Multiome | 355 | |
| chr1:159,945,025–159,946,368 | 164.8 kb | Distal (>10kb) Multiome | 624 | |
| chr1:160,031,268–160,032,381 | 251.0 kb | Distal (>10kb) Multiome | 780 | |
| chr1:160,046,290–160,047,082 | 265.7 kb | Distal (>10kb) Multiome | 540 | |
| chr1:160,069,829–160,071,049 | 289.5 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the DUSP23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.