Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Transcription factors with Perturb-seq knockdown data for DUSP18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUSP18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUSP18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:30,386,775–30,387,972 | 280.5 kb | Distal (>10kb) Multiome | 499 | |
| chr22:30,392,372–30,393,155 | 275.0 kb | Distal (>10kb) Multiome | 209 | |
| chr22:30,396,849–30,397,353 | 270.9 kb | Distal (>10kb) Multiome | 385 | |
| chr22:30,422,945–30,424,825 | 243.8 kb | Distal (>10kb) Multiome | 1038 | |
| chr22:30,425,449–30,426,228 | 242.1 kb | Distal (>10kb) Multiome | 617 | |
| chr22:30,426,363–30,426,817 | 241.1 kb | Distal (>10kb) Multiome | 374 | |
| chr22:30,574,045–30,575,001 | 93.2 kb | Distal (>10kb) Multiome | 283 | |
| chr22:30,591,677–30,592,568 | 75.7 kb | Distal (>10kb) Multiome | 698 | |
| chr22:30,606,243–30,607,508 | 61.0 kb | Distal (>10kb) Multiome | 507 | |
| chr22:30,634,485–30,636,231 | 32.2 kb | Distal (>10kb) Multiome | 611 | |
| chr22:30,667,348–30,668,634 | 3 bp | At TSS Multiome | 590 | |
| chr22:30,802,592–30,803,363 | 135.1 kb | Distal (>10kb) Multiome | 898 |
Genomic view of the DUSP18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.