Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Transcription factors with Perturb-seq knockdown data for DUSP14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUSP14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUSP14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:37,358,363–37,360,066 | 130.6 kb | Distal (>10kb) Multiome | 859 | |
| chr17:37,406,418–37,407,500 | 82.9 kb | Distal (>10kb) Multiome | 822 | |
| chr17:37,488,914–37,490,446 | 72 bp | At TSS Multiome | 759 | |
| chr17:37,608,867–37,609,901 | 119.6 kb | Distal (>10kb) Multiome | 930 | |
| chr17:37,643,162–37,643,681 | 153.6 kb | Distal (>10kb) Multiome | 540 | |
| chr17:37,709,949–37,710,763 | 220.6 kb | Distal (>10kb) Multiome | 375 | |
| chr17:37,725,144–37,726,036 | 235.6 kb | Distal (>10kb) Multiome | 148 | |
| chr17:37,743,503–37,745,720 | 255.3 kb | Distal (>10kb) Multiome | 528 |
Genomic view of the DUSP14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.