Enables mRNA dihydrouridine synthase activity and tRNA-dihydrouridine47 synthase activity. Involved in regulation of translation and tRNA dihydrouridine synthesis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DUS3L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUS3L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUS3L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:5,536,326–5,536,869 | 254.6 kb | Distal (>10kb) Multiome | 306 | |
| chr19:5,567,504–5,568,201 | 223.4 kb | Distal (>10kb) Multiome | 209 | |
| chr19:5,585,656–5,586,338 | 205.2 kb | Distal (>10kb) Multiome | 267 | |
| chr19:5,621,964–5,623,739 | 168.3 kb | Distal (>10kb) Multiome | 857 | |
| chr19:5,679,757–5,681,464 | 110.4 kb | Distal (>10kb) Multiome | 884 | |
| chr19:5,686,329–5,687,994 | 104.2 kb | Distal (>10kb) Multiome | 693 | |
| chr19:5,689,735–5,690,874 | 100.9 kb | Distal (>10kb) Multiome | 960 | |
| chr19:5,719,717–5,721,174 | 70.8 kb | Distal (>10kb) Multiome | 985 | |
| chr19:5,790,527–5,791,509 | 323 bp | At TSS Multiome | 965 | |
| chr19:5,803,750–5,806,128 | 13.9 kb | Distal (>10kb) Multiome | 858 | |
| chr19:5,826,528–5,829,726 | 36.9 kb | Distal (>10kb) Multiome | 1037 | |
| chr19:5,903,474–5,905,358 | 113.4 kb | Distal (>10kb) Multiome | 1027 | |
| chr19:5,977,406–5,978,787 | 187.0 kb | Distal (>10kb) Multiome | 1028 |
Genomic view of the DUS3L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.