DUS1L

dihydrouridine synthase 1 like | DUS1, PP3111

Enables tRNA-dihydrouridine16 synthase activity and tRNA-dihydrouridine17 synthase activity. Involved in tRNA dihydrouridine synthesis. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1

Biological processes 15 terms

cytoplasm (GO:0005737)cytoplasm (GO:0005737)flavin adenine dinucleotide binding (GO:0050660)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)tRNA dihydrouridine synthase activity (GO:0017150)tRNA dihydrouridine synthase activity (GO:0017150)tRNA dihydrouridine synthesis (GO:0002943)tRNA dihydrouridine synthesis (GO:0002943)tRNA processing (GO:0008033)tRNA-dihydrouridine16 synthase activity (GO:0102262)tRNA-dihydrouridine16 synthase activity (GO:0102262)tRNA-dihydrouridine17 synthase activity (GO:0102263)tRNA-dihydrouridine17 synthase activity (GO:0102263)

Expression (TPM)

TFs regulating DUS1L 0 TFs

Transcription factors with Perturb-seq knockdown data for DUS1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUS1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DUS1L

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUS1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:81,832,473–81,833,976	232.5 kb	Distal (>10kb) Multiome	1015
chr17:81,859,762–81,861,595	205.0 kb	Distal (>10kb) Multiome	1134
chr17:81,868,421–81,868,978	197.2 kb	Distal (>10kb) Multiome	577
chr17:81,869,000–81,872,289	194.6 kb	Distal (>10kb) Multiome	1136
chr17:81,891,143–81,892,257	174.0 kb	Distal (>10kb) Multiome	969
chr17:81,910,443–81,911,980	154.2 kb	Distal (>10kb) Multiome	806
chr17:81,917,586–81,918,522	147.6 kb	Distal (>10kb) Multiome	619
chr17:81,923,285–81,923,863	142.3 kb	Distal (>10kb) Multiome	399
chr17:81,926,141–81,929,133	137.9 kb	Distal (>10kb) Multiome	1034
chr17:81,936,855–81,937,682	128.5 kb	Distal (>10kb) Multiome	854
chr17:81,959,299–81,962,169	106.1 kb	Distal (>10kb) Multiome	805
chr17:81,966,804–81,968,359	97.7 kb	Distal (>10kb) Multiome	908
chr17:81,976,595–81,978,312	88.1 kb	Distal (>10kb) Multiome	1001
chr17:82,019,856–82,020,391	45.7 kb	Distal (>10kb) Multiome	436
chr17:82,022,355–82,024,111	42.7 kb	Distal (>10kb) Multiome	898
chr17:82,029,976–82,032,662	33.9 kb	Distal (>10kb) Multiome	695
chr17:82,036,902–82,037,961	28.2 kb	Distal (>10kb) Multiome	892
chr17:82,051,387–82,052,184	14.0 kb	Distal (>10kb) Multiome	479
chr17:82,065,558–82,066,150	25 bp	At TSS Multiome	967
chr17:82,096,478–82,100,203	32.7 kb	Distal (>10kb) Multiome	1085
chr17:82,103,334–82,104,356	37.8 kb	Distal (>10kb) Multiome	672
chr17:82,212,405–82,213,592	147.1 kb	Distal (>10kb) Multiome	911
chr17:82,228,266–82,232,536	163.2 kb	Distal (>10kb) Multiome	1048
chr17:82,272,608–82,274,062	207.9 kb	Distal (>10kb) Multiome	943
chr17:82,278,488–82,279,226	213.1 kb	Distal (>10kb) Multiome	229
chr17:82,292,400–82,293,256	227.1 kb	Distal (>10kb) Multiome	944

Genome Browser

Genomic view of the DUS1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.