Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DTX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DTX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DTX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:113,092,863–113,093,647 | 248 bp | At TSS Multiome | 192 | |
| chr12:113,098,427–113,098,674 | 4.9 kb | Proximal (<10kb) | 423 | |
| chr12:113,103,783–113,104,453 | 10.6 kb | Distal (>10kb) Multiome | 273 | |
| chr12:113,135,292–113,136,333 | 42.3 kb | Distal (>10kb) Multiome | 375 | |
| chr12:113,149,367–113,149,817 | 56.1 kb | Distal (>10kb) Multiome | 206 | |
| chr12:113,152,822–113,153,581 | 59.7 kb | Distal (>10kb) Multiome | 573 | |
| chr12:113,154,377–113,154,958 | 61.2 kb | Distal (>10kb) Multiome | 182 | |
| chr12:113,161,407–113,162,141 | 68.2 kb | Distal (>10kb) Multiome | 235 | |
| chr12:113,184,669–113,186,034 | 92.0 kb | Distal (>10kb) Multiome | 1020 | |
| chr12:113,220,621–113,222,139 | 127.8 kb | Distal (>10kb) Multiome | 818 | |
| chr12:113,245,518–113,246,307 | 152.4 kb | Distal (>10kb) Multiome | 649 | |
| chr12:113,334,690–113,335,505 | 241.7 kb | Distal (>10kb) Multiome | 685 | |
| chr12:113,358,144–113,359,258 | 265.1 kb | Distal (>10kb) Multiome | 774 |
Genomic view of the DTX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.