This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for DSN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DSN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DSN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:36,540,956–36,541,869 | 232.4 kb | Distal (>10kb) Multiome | 305 | |
| chr20:36,571,701–36,572,151 | 202.0 kb | Distal (>10kb) Multiome | 361 | |
| chr20:36,572,535–36,575,795 | 200.3 kb | Distal (>10kb) Multiome | 1083 | |
| chr20:36,585,521–36,586,119 | 188.0 kb | Distal (>10kb) Multiome | 314 | |
| chr20:36,604,973–36,606,237 | 168.1 kb | Distal (>10kb) Multiome | 1049 | |
| chr20:36,676,551–36,678,157 | 96.5 kb | Distal (>10kb) Multiome | 370 | |
| chr20:36,745,462–36,746,528 | 27.6 kb | Distal (>10kb) Multiome | 739 | |
| chr20:36,773,223–36,774,655 | 178 bp | At TSS Multiome | 971 | |
| chr20:36,821,902–36,822,404 | 48.4 kb | Distal (>10kb) Multiome | 177 | |
| chr20:36,835,484–36,836,113 | 62.0 kb | Distal (>10kb) Multiome | 446 | |
| chr20:36,846,853–36,847,425 | 73.3 kb | Distal (>10kb) Multiome | 228 | |
| chr20:36,863,126–36,864,425 | 90.1 kb | Distal (>10kb) Multiome | 833 | |
| chr20:36,886,953–36,887,714 | 113.6 kb | Distal (>10kb) Multiome | 586 | |
| chr20:36,951,062–36,952,347 | 178.0 kb | Distal (>10kb) Multiome | 859 |
Genomic view of the DSN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.