This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DRAM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DRAM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DRAM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:101,696,663–101,698,677 | 179.9 kb | Distal (>10kb) Multiome | 939 | |
| chr12:101,830,071–101,831,573 | 46.6 kb | Distal (>10kb) Multiome | 637 | |
| chr12:101,876,810–101,878,266 | 6 bp | At TSS Multiome | 1007 | |
| chr12:102,061,470–102,062,548 | 184.5 kb | Distal (>10kb) Multiome | 687 | |
| chr12:102,119,615–102,121,249 | 242.6 kb | Distal (>10kb) Multiome | 891 | |
| chr12:102,824,128–102,824,965 | 947.0 kb | Distal (>10kb) Multiome HiCAR | 512 |
Genomic view of the DRAM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.