The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DPP7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPP7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPP7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,842,325–136,842,872 | 272.2 kb | Distal (>10kb) Multiome | 492 | |
| chr9:136,846,187–136,850,214 | 265.3 kb | Distal (>10kb) Multiome | 1074 | |
| chr9:136,865,842–136,866,772 | 248.3 kb | Distal (>10kb) Multiome | 742 | |
| chr9:136,885,976–136,887,547 | 228.3 kb | Distal (>10kb) Multiome | 770 | |
| chr9:136,943,250–136,945,621 | 170.0 kb | Distal (>10kb) Multiome | 883 | |
| chr9:136,949,631–136,950,846 | 164.5 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,977,106–136,980,430 | 136.2 kb | Distal (>10kb) Multiome | 413 | |
| chr9:136,991,827–136,993,248 | 122.4 kb | Distal (>10kb) Multiome | 720 | |
| chr9:137,027,536–137,029,054 | 86.5 kb | Distal (>10kb) Multiome | 539 | |
| chr9:137,029,231–137,029,652 | 85.2 kb | Distal (>10kb) Multiome | 386 | |
| chr9:137,045,334–137,046,838 | 68.2 kb | Distal (>10kb) Multiome | 829 | |
| chr9:137,053,352–137,054,892 | 60.6 kb | Distal (>10kb) Multiome | 544 | |
| chr9:137,067,810–137,068,494 | 46.6 kb | Distal (>10kb) Multiome | 492 | |
| chr9:137,069,879–137,071,138 | 44.1 kb | Distal (>10kb) Multiome | 703 | |
| chr9:137,076,758–137,078,723 | 37.3 kb | Distal (>10kb) Multiome | 530 | |
| chr9:137,085,844–137,087,716 | 27.8 kb | Distal (>10kb) Multiome | 890 | |
| chr9:137,114,470–137,115,008 | at TSS | At TSS | 418 | |
| chr9:137,129,244–137,130,499 | 15.1 kb | Distal (>10kb) Multiome | 823 | |
| chr9:137,167,984–137,170,155 | 54.8 kb | Distal (>10kb) Multiome | 560 | |
| chr9:137,188,099–137,189,538 | 74.0 kb | Distal (>10kb) Multiome | 954 | |
| chr9:137,200,175–137,201,689 | 86.2 kb | Distal (>10kb) Multiome | 856 | |
| chr9:137,205,371–137,205,975 | 90.9 kb | Distal (>10kb) Multiome | 758 | |
| chr9:137,221,373–137,224,294 | 107.2 kb | Distal (>10kb) Multiome HiCAR | 843 | |
| chr9:137,227,249–137,228,051 | 113.0 kb | Distal (>10kb) Multiome HiCAR | 533 | |
| chr9:137,236,161–137,237,143 | 122.0 kb | Distal (>10kb) Multiome HiCAR | 748 | |
| chr9:137,239,991–137,242,933 | 126.3 kb | Distal (>10kb) Multiome | 1117 | |
| chr9:137,243,659–137,245,307 | 129.6 kb | Distal (>10kb) Multiome | 471 | |
| chr9:137,253,801–137,256,036 | 140.6 kb | Distal (>10kb) Multiome | 843 | |
| chr9:137,280,593–137,281,861 | 166.5 kb | Distal (>10kb) Multiome | 223 | |
| chr9:137,294,859–137,296,916 | 180.8 kb | Distal (>10kb) Multiome | 501 | |
| chr9:137,300,591–137,303,141 | 187.7 kb | Distal (>10kb) Multiome | 790 | |
| chr9:137,316,104–137,316,916 | 201.6 kb | Distal (>10kb) Multiome | 395 | |
| chr9:137,406,843–137,407,556 | 292.4 kb | Distal (>10kb) Multiome | 427 |
Genomic view of the DPP7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.