This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for DPP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:66,256,991–66,258,893 | 222.5 kb | Distal (>10kb) Multiome | 844 | |
| chr11:66,266,650–66,269,501 | 212.9 kb | Distal (>10kb) Multiome | 869 | |
| chr11:66,277,646–66,278,447 | 202.3 kb | Distal (>10kb) Multiome | 363 | |
| chr11:66,282,288–66,283,017 | 197.8 kb | Distal (>10kb) Multiome | 618 | |
| chr11:66,288,772–66,289,992 | 191.1 kb | Distal (>10kb) Multiome | 944 | |
| chr11:66,311,658–66,313,958 | 168.3 kb | Distal (>10kb) Multiome | 1005 | |
| chr11:66,316,861–66,317,347 | 163.3 kb | Distal (>10kb) Multiome | 164 | |
| chr11:66,328,223–66,328,781 | 151.9 kb | Distal (>10kb) Multiome | 662 | |
| chr11:66,344,804–66,345,488 | 135.3 kb | Distal (>10kb) Multiome | 731 | |
| chr11:66,347,078–66,348,463 | 132.6 kb | Distal (>10kb) Multiome | 866 | |
| chr11:66,370,733–66,372,576 | 108.6 kb | Distal (>10kb) Multiome | 800 | |
| chr11:66,408,467–66,409,206 | 71.7 kb | Distal (>10kb) Multiome | 569 | |
| chr11:66,421,258–66,422,129 | 58.7 kb | Distal (>10kb) Multiome | 1190 | |
| chr11:66,438,544–66,439,241 | 41.5 kb | Distal (>10kb) Multiome | 756 | |
| chr11:66,466,155–66,467,634 | 13.6 kb | Distal (>10kb) Multiome | 579 | |
| chr11:66,479,578–66,480,947 | 55 bp | At TSS Multiome | 937 | |
| chr11:66,510,277–66,510,954 | 30.2 kb | Distal (>10kb) Multiome | 787 | |
| chr11:66,545,631–66,547,072 | 65.7 kb | Distal (>10kb) Multiome | 753 | |
| chr11:66,568,061–66,568,910 | 88.1 kb | Distal (>10kb) Multiome | 392 | |
| chr11:66,592,561–66,593,452 | 112.6 kb | Distal (>10kb) Multiome | 857 | |
| chr11:66,616,078–66,617,408 | 136.1 kb | Distal (>10kb) Multiome | 1011 | |
| chr11:66,637,919–66,639,003 | 158.1 kb | Distal (>10kb) Multiome | 872 | |
| chr11:66,677,182–66,678,796 | 197.5 kb | Distal (>10kb) Multiome HiCAR | 926 | |
| chr11:66,728,259–66,728,943 | 248.0 kb | Distal (>10kb) Multiome | 275 | |
| chr11:66,744,354–66,745,291 | 264.3 kb | Distal (>10kb) Multiome | 747 |
Genomic view of the DPP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.