The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for DOK5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DOK5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DOK5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:54,207,506–54,209,250 | 267.7 kb | Distal (>10kb) Multiome | 1046 | |
| chr20:54,223,363–54,224,391 | 251.6 kb | Distal (>10kb) Multiome | 143 | |
| chr20:54,385,104–54,385,871 | 90.1 kb | Distal (>10kb) Multiome | 96 | |
| chr20:54,469,396–54,469,566 | 6.1 kb | Proximal (<10kb) | 29 | |
| chr20:54,474,748–54,476,808 | at TSS | At TSS Multiome | 269 | |
| chr20:54,479,701–54,479,914 | 4.1 kb | Proximal (<10kb) | 90 | |
| chr20:56,358,373–56,359,678 | 1883.3 kb | Distal (>10kb) Multiome HiCAR | 612 |
Genomic view of the DOK5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.