Predicted to be involved in Ras protein signal transduction and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in ficolin-1-rich granule membrane and plasma membrane. Predicted to be active in cytoplasm. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DOK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DOK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DOK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:177,303,008–177,304,238 | 207.6 kb | Distal (>10kb) Multiome | 850 | |
| chr5:177,309,549–177,310,172 | 201.4 kb | Distal (>10kb) Multiome | 373 | |
| chr5:177,311,267–177,313,178 | 199.0 kb | Distal (>10kb) Multiome | 798 | |
| chr5:177,351,374–177,352,243 | 159.4 kb | Distal (>10kb) Multiome | 832 | |
| chr5:177,362,756–177,363,624 | 148.1 kb | Distal (>10kb) Multiome | 479 | |
| chr5:177,366,082–177,368,548 | 144.1 kb | Distal (>10kb) Multiome | 626 | |
| chr5:177,370,255–177,371,449 | 140.4 kb | Distal (>10kb) Multiome | 584 | |
| chr5:177,402,327–177,404,671 | 106.8 kb | Distal (>10kb) Multiome | 807 | |
| chr5:177,425,334–177,427,296 | 84.8 kb | Distal (>10kb) Multiome | 982 | |
| chr5:177,446,196–177,448,203 | 64.5 kb | Distal (>10kb) Multiome | 826 | |
| chr5:177,453,910–177,456,838 | 55.8 kb | Distal (>10kb) Multiome | 1057 | |
| chr5:177,457,280–177,458,365 | 53.5 kb | Distal (>10kb) Multiome | 321 | |
| chr5:177,472,252–177,474,487 | 38.6 kb | Distal (>10kb) Multiome | 546 | |
| chr5:177,491,301–177,491,987 | 19.7 kb | Distal (>10kb) Multiome | 522 | |
| chr5:177,494,661–177,498,477 | 15.6 kb | Distal (>10kb) Multiome | 915 | |
| chr5:177,500,863–177,501,460 | 10.1 kb | Distal (>10kb) Multiome HiCAR | 378 | |
| chr5:177,516,515–177,517,551 | 5.8 kb | Proximal (<10kb) Multiome | 958 | |
| chr5:177,553,719–177,554,931 | 43.3 kb | Distal (>10kb) Multiome | 671 | |
| chr5:177,591,993–177,592,765 | 80.9 kb | Distal (>10kb) Multiome | 724 | |
| chr5:177,599,409–177,600,500 | 88.8 kb | Distal (>10kb) Multiome | 871 | |
| chr5:177,607,310–177,608,120 | 96.4 kb | Distal (>10kb) Multiome | 392 |
Genomic view of the DOK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.