The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for DOCK7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DOCK7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DOCK7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:62,435,836–62,437,694 | 251.9 kb | Distal (>10kb) Multiome | 1064 | |
| chr1:62,687,521–62,689,077 | 15 bp | At TSS Multiome | 801 | |
| chr1:62,755,859–62,756,678 | 67.9 kb | Distal (>10kb) Multiome | 17 | |
| chr1:62,759,587–62,761,031 | 72.0 kb | Distal (>10kb) Multiome | 228 | |
| chr1:62,783,470–62,784,647 | 95.6 kb | Distal (>10kb) Multiome | 840 | |
| chr1:62,963,053–62,963,671 | 274.9 kb | Distal (>10kb) Multiome | 196 |
Genomic view of the DOCK7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.