There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for DOC2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DOC2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DOC2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:29,784,957–29,785,426 | 236.0 kb | Distal (>10kb) Multiome | 452 | |
| chr16:29,790,073–29,791,192 | 230.7 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:29,804,592–29,808,172 | 215.5 kb | Distal (>10kb) Multiome HiCAR | 1275 | |
| chr16:29,810,746–29,812,649 | 208.9 kb | Distal (>10kb) Multiome HiCAR | 826 | |
| chr16:29,815,828–29,817,186 | 205.1 kb | Distal (>10kb) Multiome HiCAR | 1006 | |
| chr16:29,862,597–29,863,901 | 157.9 kb | Distal (>10kb) Multiome HiCAR | 953 | |
| chr16:29,876,281–29,878,282 | 143.6 kb | Distal (>10kb) Multiome HiCAR | 319 | |
| chr16:29,899,174–29,900,833 | 121.8 kb | Distal (>10kb) Multiome | 1019 | |
| chr16:29,925,692–29,926,784 | 95.1 kb | Distal (>10kb) Multiome | 912 | |
| chr16:29,961,477–29,962,530 | 59.3 kb | Distal (>10kb) Multiome | 848 | |
| chr16:29,973,238–29,974,906 | 47.6 kb | Distal (>10kb) Multiome | 935 | |
| chr16:29,994,888–29,996,728 | 25.1 kb | Distal (>10kb) Multiome | 1080 | |
| chr16:30,021,215–30,021,860 | 267 bp | At TSS Multiome | 764 | |
| chr16:30,052,803–30,053,364 | 31.8 kb | Distal (>10kb) Multiome | 989 | |
| chr16:30,063,722–30,066,296 | 42.8 kb | Distal (>10kb) Multiome | 1209 | |
| chr16:30,075,490–30,076,439 | 54.7 kb | Distal (>10kb) Multiome | 828 | |
| chr16:30,090,881–30,092,910 | 71.6 kb | Distal (>10kb) Multiome | 1101 | |
| chr16:30,095,557–30,096,839 | 75.0 kb | Distal (>10kb) Multiome | 824 | |
| chr16:30,122,728–30,123,578 | 102.0 kb | Distal (>10kb) Multiome | 718 | |
| chr16:30,182,759–30,183,865 | 162.1 kb | Distal (>10kb) Multiome | 547 |
Genomic view of the DOC2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.