The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for DNPEP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNPEP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNPEP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:219,159,910–219,161,297 | 227.3 kb | Distal (>10kb) Multiome | 901 | |
| chr2:219,176,168–219,177,450 | 211.1 kb | Distal (>10kb) Multiome | 999 | |
| chr2:219,177,596–219,178,930 | 209.7 kb | Distal (>10kb) Multiome | 930 | |
| chr2:219,206,194–219,207,456 | 181.0 kb | Distal (>10kb) Multiome | 861 | |
| chr2:219,217,908–219,219,751 | 168.9 kb | Distal (>10kb) Multiome | 1058 | |
| chr2:219,228,940–219,230,470 | 158.3 kb | Distal (>10kb) Multiome | 914 | |
| chr2:219,245,074–219,245,804 | 142.5 kb | Distal (>10kb) Multiome | 891 | |
| chr2:219,252,908–219,254,656 | 133.9 kb | Distal (>10kb) Multiome | 808 | |
| chr2:219,277,516–219,280,537 | 108.6 kb | Distal (>10kb) Multiome | 1073 | |
| chr2:219,294,524–219,295,391 | 93.0 kb | Distal (>10kb) Multiome | 892 | |
| chr2:219,308,224–219,309,089 | 79.6 kb | Distal (>10kb) Multiome | 742 | |
| chr2:219,386,994–219,389,117 | 318 bp | At TSS Multiome | 911 | |
| chr2:219,402,761–219,403,203 | 15.1 kb | Distal (>10kb) Multiome | 234 | |
| chr2:219,418,154–219,419,089 | 30.8 kb | Distal (>10kb) Multiome | 147 | |
| chr2:219,433,920–219,435,459 | 46.3 kb | Distal (>10kb) Multiome | 315 | |
| chr2:219,441,439–219,442,557 | 54.0 kb | Distal (>10kb) Multiome | 338 | |
| chr2:219,447,946–219,449,531 | 60.9 kb | Distal (>10kb) Multiome | 244 | |
| chr2:219,476,330–219,477,528 | 88.8 kb | Distal (>10kb) Multiome | 373 | |
| chr2:219,484,139–219,485,299 | 97.0 kb | Distal (>10kb) Multiome | 146 | |
| chr2:219,497,658–219,499,313 | 110.8 kb | Distal (>10kb) Multiome | 907 | |
| chr2:219,506,707–219,507,641 | 119.2 kb | Distal (>10kb) Multiome | 205 | |
| chr2:219,509,036–219,510,612 | 122.2 kb | Distal (>10kb) Multiome | 614 | |
| chr2:219,521,083–219,521,760 | 133.5 kb | Distal (>10kb) Multiome | 325 | |
| chr2:219,522,621–219,523,337 | 135.1 kb | Distal (>10kb) Multiome | 201 | |
| chr2:219,525,558–219,526,393 | 138.1 kb | Distal (>10kb) Multiome | 321 | |
| chr2:219,530,046–219,530,655 | 142.4 kb | Distal (>10kb) Multiome | 480 | |
| chr2:219,541,583–219,542,284 | 153.9 kb | Distal (>10kb) Multiome | 764 | |
| chr2:219,542,939–219,544,543 | 156.0 kb | Distal (>10kb) Multiome | 981 | |
| chr2:219,551,360–219,553,449 | 164.6 kb | Distal (>10kb) Multiome | 785 | |
| chr2:219,570,096–219,572,421 | 183.7 kb | Distal (>10kb) Multiome | 948 | |
| chr2:219,597,186–219,598,527 | 210.1 kb | Distal (>10kb) Multiome | 955 | |
| chr2:219,627,103–219,628,325 | 239.8 kb | Distal (>10kb) Multiome | 315 | |
| chr2:219,642,343–219,643,046 | 254.7 kb | Distal (>10kb) Multiome | 686 | |
| chr2:219,684,717–219,685,631 | 297.3 kb | Distal (>10kb) Multiome | 403 |
Genomic view of the DNPEP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.