Enables protein folding chaperone. Involved in chaperone-mediated protein complex assembly. Located in nucleoplasm. Is active in cytosol; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DNLZ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNLZ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNLZ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,094,901–136,095,992 | 268.3 kb | Distal (>10kb) Multiome | 445 | |
| chr9:136,109,321–136,110,010 | 254.1 kb | Distal (>10kb) Multiome | 643 | |
| chr9:136,117,952–136,119,826 | 244.9 kb | Distal (>10kb) Multiome | 931 | |
| chr9:136,132,442–136,133,645 | 230.5 kb | Distal (>10kb) Multiome | 343 | |
| chr9:136,245,219–136,246,310 | 117.9 kb | Distal (>10kb) Multiome | 608 | |
| chr9:136,267,002–136,267,928 | 96.4 kb | Distal (>10kb) Multiome | 459 | |
| chr9:136,327,140–136,327,919 | 36.2 kb | Distal (>10kb) Multiome | 310 | |
| chr9:136,342,464–136,343,245 | 20.8 kb | Distal (>10kb) Multiome | 326 | |
| chr9:136,362,899–136,364,677 | 382 bp | At TSS Multiome | 969 | |
| chr9:136,399,639–136,400,642 | 36.5 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,410,307–136,410,943 | 46.9 kb | Distal (>10kb) Multiome | 740 | |
| chr9:136,438,826–136,440,227 | 76.1 kb | Distal (>10kb) Multiome | 608 | |
| chr9:136,482,405–136,485,297 | 119.6 kb | Distal (>10kb) Multiome | 938 | |
| chr9:136,545,392–136,547,129 | 182.4 kb | Distal (>10kb) Multiome | 710 | |
| chr9:136,572,053–136,572,865 | 208.6 kb | Distal (>10kb) Multiome | 239 | |
| chr9:136,587,135–136,588,835 | 224.6 kb | Distal (>10kb) Multiome | 453 | |
| chr9:136,626,479–136,627,366 | 263.2 kb | Distal (>10kb) Multiome | 451 | |
| chr9:136,665,223–136,666,507 | 302.1 kb | Distal (>10kb) Multiome HiCAR | 409 |
Genomic view of the DNLZ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.