This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for DNAJC7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJC7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJC7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:40,054,311–40,054,810 | 1963.1 kb | Distal (>10kb) Multiome HiCAR | 694 | |
| chr17:40,177,152–40,178,398 | 1840.1 kb | Distal (>10kb) Multiome HiCAR | 329 | |
| chr17:41,733,761–41,735,187 | 282.9 kb | Distal (>10kb) Multiome | 577 | |
| chr17:41,738,054–41,738,690 | 279.4 kb | Distal (>10kb) Multiome | 596 | |
| chr17:41,784,980–41,787,229 | 230.8 kb | Distal (>10kb) Multiome | 958 | |
| chr17:41,793,527–41,794,326 | 223.7 kb | Distal (>10kb) Multiome | 597 | |
| chr17:41,800,647–41,802,040 | 215.7 kb | Distal (>10kb) Multiome | 766 | |
| chr17:41,811,252–41,813,275 | 204.7 kb | Distal (>10kb) Multiome | 997 | |
| chr17:41,835,756–41,836,400 | 181.4 kb | Distal (>10kb) Multiome | 568 | |
| chr17:41,864,608–41,865,695 | 152.2 kb | Distal (>10kb) Multiome | 913 | |
| chr17:41,913,670–41,914,569 | 103.6 kb | Distal (>10kb) Multiome | 190 | |
| chr17:41,918,026–41,919,794 | 98.4 kb | Distal (>10kb) Multiome | 956 | |
| chr17:41,930,220–41,930,908 | 87.1 kb | Distal (>10kb) Multiome | 915 | |
| chr17:41,965,771–41,967,327 | 50.8 kb | Distal (>10kb) Multiome | 920 | |
| chr17:42,016,953–42,018,102 | 146 bp | At TSS Multiome | 991 | |
| chr17:42,019,726–42,020,334 | 2.4 kb | Proximal (<10kb) Multiome | 791 | |
| chr17:42,024,991–42,025,187 | 7.8 kb | Proximal (<10kb) | 476 | |
| chr17:42,050,326–42,051,046 | 33.0 kb | Distal (>10kb) Multiome | 514 | |
| chr17:42,107,497–42,108,335 | 90.2 kb | Distal (>10kb) Multiome HiCAR | 357 | |
| chr17:42,120,858–42,121,715 | 103.6 kb | Distal (>10kb) Multiome | 559 | |
| chr17:42,122,176–42,123,003 | 105.1 kb | Distal (>10kb) Multiome | 169 | |
| chr17:42,154,717–42,156,309 | 137.5 kb | Distal (>10kb) Multiome | 770 | |
| chr17:42,180,242–42,180,762 | 162.7 kb | Distal (>10kb) Multiome | 576 | |
| chr17:42,183,755–42,184,761 | 166.6 kb | Distal (>10kb) Multiome | 810 | |
| chr17:42,275,506–42,277,052 | 258.8 kb | Distal (>10kb) Multiome | 892 | |
| chr17:42,288,257–42,288,808 | 270.9 kb | Distal (>10kb) Multiome | 449 | |
| chr17:42,312,237–42,312,887 | 294.8 kb | Distal (>10kb) Multiome | 774 | |
| chr17:42,535,863–42,536,855 | 518.8 kb | Distal (>10kb) Multiome HiCAR | 987 |
Genomic view of the DNAJC7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.