Transcription factors with Perturb-seq knockdown data for DNAJC3-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJC3-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJC3-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:95,403,573–95,404,765 | 272.8 kb | Distal (>10kb) Multiome | 412 | |
| chr13:95,552,034–95,553,905 | 124.3 kb | Distal (>10kb) Multiome | 283 | |
| chr13:95,641,248–95,642,446 | 35.0 kb | Distal (>10kb) Multiome HiCAR | 290 | |
| chr13:95,643,560–95,645,129 | 32.3 kb | Distal (>10kb) Multiome HiCAR | 600 | |
| chr13:95,676,126–95,678,015 | 51 bp | At TSS Multiome | 948 | |
| chr13:95,684,552–95,684,786 | 7.6 kb | Proximal (<10kb) | 24 |
Genomic view of the DNAJC3-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.