Predicted to enable Hsp70 protein binding activity. Predicted to be involved in cellular response to misfolded protein and chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for DNAJC18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJC18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJC18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:139,197,672–139,198,627 | 241.1 kb | Distal (>10kb) Multiome | 851 | |
| chr5:139,273,424–139,274,448 | 165.4 kb | Distal (>10kb) Multiome | 843 | |
| chr5:139,283,068–139,284,092 | 155.8 kb | Distal (>10kb) Multiome | 194 | |
| chr5:139,293,312–139,294,807 | 145.8 kb | Distal (>10kb) Multiome | 994 | |
| chr5:139,341,351–139,342,686 | 97.6 kb | Distal (>10kb) Multiome | 1002 | |
| chr5:139,378,115–139,378,885 | 61.0 kb | Distal (>10kb) Multiome | 122 | |
| chr5:139,391,978–139,393,556 | 46.7 kb | Distal (>10kb) Multiome | 424 | |
| chr5:139,396,045–139,397,275 | 42.6 kb | Distal (>10kb) Multiome | 134 | |
| chr5:139,403,383–139,404,694 | 35.4 kb | Distal (>10kb) Multiome | 772 | |
| chr5:139,438,861–139,439,913 | 70 bp | At TSS Multiome | 726 | |
| chr5:139,517,739–139,518,561 | 78.7 kb | Distal (>10kb) Multiome HiCAR | 1046 | |
| chr5:139,523,548–139,524,678 | 84.7 kb | Distal (>10kb) Multiome | 320 | |
| chr5:139,560,824–139,562,261 | 121.8 kb | Distal (>10kb) Multiome | 970 | |
| chr5:139,637,254–139,638,208 | 198.2 kb | Distal (>10kb) Multiome | 890 | |
| chr5:139,646,902–139,649,971 | 209.1 kb | Distal (>10kb) Multiome | 723 | |
| chr5:139,668,261–139,668,827 | 229.0 kb | Distal (>10kb) Multiome | 388 | |
| chr5:139,696,560–139,698,449 | 258.0 kb | Distal (>10kb) Multiome | 789 | |
| chr5:139,698,576–139,699,204 | 259.5 kb | Distal (>10kb) Multiome | 291 | |
| chr5:139,700,801–139,701,790 | 262.0 kb | Distal (>10kb) Multiome | 520 | |
| chr5:139,708,355–139,712,383 | 270.0 kb | Distal (>10kb) Multiome | 1075 |
Genomic view of the DNAJC18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.