The membrane protein encoded by this gene is a DNAJ-like heat shock protein that binds the molecular chaperone BiP. In addition, the encoded protein contains two SANT domains that have been shown to bind serpin alpha1-antichymotrypsin and inter-alpha trypsin inhibitor heavy chain 4. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for DNAJC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:21,727,364–21,728,215 | 275.9 kb | Distal (>10kb) Multiome | 323 | |
| chr10:21,751,037–21,752,796 | 252.1 kb | Distal (>10kb) Multiome | 246 | |
| chr10:22,002,717–22,004,030 | 42 bp | At TSS Multiome | 868 | |
| chr10:22,016,870–22,017,923 | 13.7 kb | Distal (>10kb) Multiome | 347 | |
| chr10:22,228,979–22,229,717 | 225.6 kb | Distal (>10kb) Multiome HiCAR | 978 | |
| chr10:22,243,000–22,244,484 | 240.1 kb | Distal (>10kb) Multiome | 178 | |
| chr10:22,251,767–22,253,798 | 248.8 kb | Distal (>10kb) Multiome | 470 | |
| chr10:22,315,958–22,317,121 | 312.6 kb | Distal (>10kb) Multiome HiCAR | 907 |
Genomic view of the DNAJC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.