Enables Arp2/3 complex binding activity. Involved in negative regulation of Arp2/3 complex-mediated actin nucleation and negative regulation of cell migration. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DNAI3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAI3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAI3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:84,892,367–84,893,746 | 169.2 kb | Distal (>10kb) Multiome | 406 | |
| chr1:84,944,592–84,945,445 | 117.3 kb | Distal (>10kb) Multiome | 438 | |
| chr1:84,996,442–84,998,604 | 65.2 kb | Distal (>10kb) Multiome | 490 | |
| chr1:85,047,243–85,049,064 | 14.1 kb | Distal (>10kb) Multiome | 533 | |
| chr1:85,054,792–85,054,968 | 7.4 kb | Proximal (<10kb) | 12 | |
| chr1:85,061,692–85,062,785 | 107 bp | At TSS Multiome | 384 | |
| chr1:85,200,160–85,202,231 | 139.4 kb | Distal (>10kb) Multiome | 895 | |
| chr1:85,224,822–85,225,910 | 162.9 kb | Distal (>10kb) Multiome | 499 | |
| chr1:85,258,924–85,260,262 | 197.4 kb | Distal (>10kb) Multiome HiCAR | 782 | |
| chr1:85,275,751–85,277,437 | 214.3 kb | Distal (>10kb) Multiome | 868 | |
| chr1:85,307,937–85,308,862 | 245.9 kb | Distal (>10kb) Multiome | 554 |
Genomic view of the DNAI3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.