DNAH7 is a component of the inner dynein arm of ciliary axonemes (Zhang et al., 2002 [PubMed 11877439]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for DNAH7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAH7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAH7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:196,059,252–196,060,229 | 8.6 kb | Proximal (<10kb) | 200 | |
| chr2:196,066,928–196,067,105 | 1.7 kb | Proximal (<10kb) | 69 | |
| chr2:196,068,113–196,069,234 | 177 bp | At TSS Multiome | 800 | |
| chr2:196,077,439–196,077,669 | 8.6 kb | Proximal (<10kb) | 22 | |
| chr2:196,078,339–196,078,875 | 9.5 kb | Proximal (<10kb) | 188 | |
| chr2:196,170,221–196,172,307 | 103.2 kb | Distal (>10kb) Multiome | 873 |
Genomic view of the DNAH7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.