This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for DMXL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DMXL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DMXL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:51,341,359–51,342,151 | 280.9 kb | Distal (>10kb) Multiome | 227 | |
| chr15:51,407,071–51,407,878 | 215.4 kb | Distal (>10kb) Multiome | 99 | |
| chr15:51,621,891–51,623,295 | 77 bp | At TSS Multiome | 786 | |
| chr15:51,681,155–51,681,883 | 58.8 kb | Distal (>10kb) Multiome | 662 | |
| chr15:51,726,326–51,726,848 | 103.8 kb | Distal (>10kb) Multiome | 334 | |
| chr15:51,736,980–51,738,047 | 114.8 kb | Distal (>10kb) Multiome | 521 | |
| chr15:51,751,070–51,752,267 | 128.8 kb | Distal (>10kb) Multiome | 433 | |
| chr15:51,829,316–51,830,426 | 207.0 kb | Distal (>10kb) Multiome | 787 |
Genomic view of the DMXL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.