DMWD

DM1 locus, WD repeat containing | D19S593E, DMR-N9, gene59

Enables deubiquitinase activator activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 13 terms

cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)dendrite (GO:0030425)deubiquitinase activator activity (GO:0035800)deubiquitinase activator activity (GO:0035800)negative regulation of ubiquitin-dependent protein catabolic process (GO:2000059)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)perikaryon (GO:0043204)protein binding (GO:0005515)

Expression (TPM)

TFs regulating DMWD 0 TFs

Transcription factors with Perturb-seq knockdown data for DMWD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DMWD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DMWD

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DMWD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:45,492,647–45,493,344	299.9 kb	Distal (>10kb) Multiome	522
chr19:45,496,247–45,497,677	295.7 kb	Distal (>10kb) Multiome	742
chr19:45,498,270–45,499,916	293.2 kb	Distal (>10kb) Multiome	464
chr19:45,506,243–45,507,963	286.1 kb	Distal (>10kb) Multiome	969
chr19:45,508,291–45,509,751	284.1 kb	Distal (>10kb) Multiome	670
chr19:45,528,315–45,529,353	263.9 kb	Distal (>10kb) Multiome	425
chr19:45,584,026–45,585,251	208.1 kb	Distal (>10kb) Multiome	907
chr19:45,607,096–45,607,695	185.4 kb	Distal (>10kb) Multiome	526
chr19:45,615,654–45,616,944	176.6 kb	Distal (>10kb) Multiome	480
chr19:45,632,406–45,633,148	160.1 kb	Distal (>10kb) Multiome	358
chr19:45,638,965–45,639,696	153.4 kb	Distal (>10kb) Multiome	477
chr19:45,640,813–45,642,557	150.5 kb	Distal (>10kb) Multiome	865
chr19:45,643,187–45,644,012	149.2 kb	Distal (>10kb) Multiome	542
chr19:45,645,389–45,646,343	146.9 kb	Distal (>10kb) Multiome	566
chr19:45,667,856–45,668,417	124.7 kb	Distal (>10kb) Multiome	386
chr19:45,668,914–45,669,719	123.4 kb	Distal (>10kb) Multiome	611
chr19:45,670,481–45,671,446	121.7 kb	Distal (>10kb) Multiome	361
chr19:45,676,875–45,678,209	115.3 kb	Distal (>10kb) Multiome	418
chr19:45,681,530–45,682,004	111.1 kb	Distal (>10kb) Multiome	648
chr19:45,691,622–45,693,062	100.4 kb	Distal (>10kb) Multiome	943
chr19:45,716,851–45,718,343	75.2 kb	Distal (>10kb) Multiome	895
chr19:45,730,200–45,731,219	61.8 kb	Distal (>10kb) Multiome	740
chr19:45,767,223–45,771,892	23.4 kb	Distal (>10kb) Multiome	1161
chr19:45,779,258–45,780,150	13.2 kb	Distal (>10kb) Multiome	445
chr19:45,792,338–45,793,273	122 bp	At TSS Multiome	609
chr19:45,799,159–45,799,328	6.4 kb	Proximal (<10kb)	277
chr19:45,815,484–45,818,073	23.1 kb	Distal (>10kb) Multiome	623
chr19:45,862,559–45,864,765	71.6 kb	Distal (>10kb) Multiome	976
chr19:45,881,480–45,883,645	89.3 kb	Distal (>10kb) Multiome	990
chr19:45,885,092–45,887,294	93.9 kb	Distal (>10kb) Multiome	913
chr19:45,901,212–45,903,471	110.1 kb	Distal (>10kb) Multiome	780
chr19:45,952,967–45,953,485	160.3 kb	Distal (>10kb) Multiome	329
chr19:45,973,761–45,974,227	181.3 kb	Distal (>10kb) Multiome	201
chr19:45,994,774–45,995,740	202.5 kb	Distal (>10kb) Multiome	660
chr19:46,014,941–46,015,784	222.6 kb	Distal (>10kb) Multiome	220
chr19:46,016,414–46,017,078	224.1 kb	Distal (>10kb) Multiome	364
chr19:46,076,819–46,077,882	284.9 kb	Distal (>10kb) Multiome	516

Genome Browser

Genomic view of the DMWD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.