DMBX1

diencephalon/mesencephalon homeobox 1 | Atx, MBX, PAXB, OTX3

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Biological processes 29 terms

DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)brain development (GO:0007420)brain development (GO:0007420)central nervous system development (GO:0007417)central nervous system development (GO:0007417)chromatin (GO:0000785)developmental growth (GO:0048589)developmental growth (GO:0048589)identical protein binding (GO:0042802)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)transcription regulator complex (GO:0005667)

Expression (TPM)

TFs regulating DMBX1 0 TFs

Transcription factors with Perturb-seq knockdown data for DMBX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DMBX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DMBX1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DMBX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:46,198,117–46,198,832	291.4 kb	Distal (>10kb) Multiome	646
chr1:46,203,021–46,203,710	286.5 kb	Distal (>10kb) Multiome	394
chr1:46,246,904–46,248,623	242.3 kb	Distal (>10kb) Multiome	923
chr1:46,301,645–46,303,965	187.9 kb	Distal (>10kb) Multiome	1035
chr1:46,340,061–46,341,413	149.1 kb	Distal (>10kb) Multiome	967
chr1:46,394,021–46,394,849	95.4 kb	Distal (>10kb) Multiome	795
chr1:46,401,942–46,402,392	87.6 kb	Distal (>10kb) Multiome	511
chr1:46,406,082–46,407,120	83.3 kb	Distal (>10kb) Multiome	299
chr1:46,442,171–46,443,351	47.2 kb	Distal (>10kb) Multiome HiCAR	649
chr1:46,448,113–46,448,679	41.4 kb	Distal (>10kb) Multiome HiCAR	143
chr1:46,466,221–46,467,348	23.2 kb	Distal (>10kb) Multiome	398
chr1:46,485,537–46,486,036	3.8 kb	Proximal (<10kb)	74
chr1:46,487,884–46,488,071	1.8 kb	Proximal (<10kb)	115
chr1:46,489,045–46,490,312	94 bp	At TSS Multiome	381
chr1:46,516,974–46,517,563	27.4 kb	Distal (>10kb) Multiome HiCAR	328
chr1:46,526,636–46,527,311	37.2 kb	Distal (>10kb) Multiome HiCAR	225
chr1:46,532,918–46,533,689	43.4 kb	Distal (>10kb) Multiome HiCAR	254
chr1:46,603,644–46,604,906	114.4 kb	Distal (>10kb) Multiome	784
chr1:46,616,228–46,617,226	126.8 kb	Distal (>10kb) Multiome	517
chr1:46,667,821–46,668,764	178.6 kb	Distal (>10kb) Multiome	668
chr1:46,718,615–46,719,657	229.4 kb	Distal (>10kb) Multiome	860

Genome Browser

Genomic view of the DMBX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.