This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DMAC2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DMAC2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DMAC2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:50,116,214–50,116,984 | 195.7 kb | Distal (>10kb) Multiome | 818 | |
| chr14:50,231,069–50,232,486 | 80.5 kb | Distal (>10kb) Multiome | 823 | |
| chr14:50,311,389–50,313,095 | 10 bp | At TSS Multiome | 986 | |
| chr14:50,321,100–50,321,313 | 8.8 kb | Proximal (<10kb) | 457 | |
| chr14:50,396,285–50,397,366 | 84.5 kb | Distal (>10kb) Multiome | 782 | |
| chr14:50,531,734–50,533,317 | 220.3 kb | Distal (>10kb) Multiome HiCAR | 905 | |
| chr14:50,559,970–50,561,283 | 248.2 kb | Distal (>10kb) Multiome | 524 |
Genomic view of the DMAC2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.