Transcription factors with Perturb-seq knockdown data for DLX2-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLX2-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLX2-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:172,094,487–172,096,060 | 6.9 kb | Proximal (<10kb) | 520 | |
| chr2:172,098,856–172,099,420 | 3.6 kb | Proximal (<10kb) | 695 | |
| chr2:172,100,160–172,100,543 | 2.5 kb | Proximal (<10kb) | 167 | |
| chr2:172,101,429–172,103,305 | at TSS | At TSS | 953 | |
| chr2:172,103,912–172,104,129 | 907 bp | At TSS | 477 | |
| chr2:172,106,181–172,106,692 | 3.2 kb | Proximal (<10kb) | 308 |
Genomic view of the DLX2-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.