Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DLX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:172,094,487–172,096,060 | 6.8 kb | Proximal (<10kb) | 520 | |
| chr2:172,098,856–172,099,420 | 3.5 kb | Proximal (<10kb) | 695 | |
| chr2:172,100,160–172,100,543 | 2.4 kb | Proximal (<10kb) | 167 | |
| chr2:172,101,429–172,103,305 | at TSS | At TSS | 953 | |
| chr2:172,103,912–172,104,129 | 1.0 kb | Proximal (<10kb) | 477 | |
| chr2:172,106,181–172,106,692 | 3.3 kb | Proximal (<10kb) | 308 |
Genomic view of the DLX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.