The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for DIS3L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DIS3L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DIS3L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:231,661,829–231,663,079 | 299.3 kb | Distal (>10kb) Multiome | 645 | |
| chr2:231,666,093–231,667,175 | 295.1 kb | Distal (>10kb) Multiome | 778 | |
| chr2:231,672,732–231,673,910 | 288.3 kb | Distal (>10kb) Multiome | 570 | |
| chr2:231,674,697–231,675,325 | 286.7 kb | Distal (>10kb) Multiome | 455 | |
| chr2:231,679,801–231,681,869 | 280.5 kb | Distal (>10kb) Multiome | 959 | |
| chr2:231,687,250–231,687,863 | 274.3 kb | Distal (>10kb) Multiome | 640 | |
| chr2:231,706,062–231,711,186 | 253.4 kb | Distal (>10kb) Multiome | 1322 | |
| chr2:231,713,567–231,715,698 | 246.4 kb | Distal (>10kb) Multiome | 974 | |
| chr2:231,780,605–231,781,892 | 180.3 kb | Distal (>10kb) Multiome | 832 | |
| chr2:231,786,115–231,787,127 | 175.2 kb | Distal (>10kb) Multiome | 1074 | |
| chr2:231,924,925–231,927,159 | 36.4 kb | Distal (>10kb) Multiome | 655 | |
| chr2:231,961,157–231,962,183 | 38 bp | At TSS Multiome | 981 |
Genomic view of the DIS3L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.