This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for DHRS7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHRS7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHRS7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:59,630,298–59,630,972 | 534.8 kb | Distal (>10kb) Multiome HiCAR | 239 | |
| chr14:59,870,241–59,871,387 | 294.6 kb | Distal (>10kb) Multiome | 433 | |
| chr14:59,919,228–59,920,620 | 245.4 kb | Distal (>10kb) Multiome | 615 | |
| chr14:60,091,167–60,092,522 | 73.4 kb | Distal (>10kb) Multiome | 1039 | |
| chr14:60,161,475–60,161,893 | 3.5 kb | Proximal (<10kb) | 92 | |
| chr14:60,164,676–60,165,904 | 74 bp | At TSS Multiome | 793 | |
| chr14:60,247,765–60,250,615 | 83.8 kb | Distal (>10kb) Multiome | 1091 | |
| chr14:60,331,221–60,332,142 | 166.4 kb | Distal (>10kb) Multiome | 515 |
Genomic view of the DHRS7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.