Enables identical protein binding activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including ketone metabolic process; positive regulation of reactive oxygen species metabolic process; and steroid metabolic process. Located in nucleus and peroxisomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DHRS4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHRS4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHRS4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:23,567,065–23,567,976 | 386.1 kb | Distal (>10kb) Multiome HiCAR | 855 | |
| chr14:23,575,776–23,576,501 | 377.5 kb | Distal (>10kb) Multiome HiCAR | 163 | |
| chr14:23,589,018–23,589,481 | 364.6 kb | Distal (>10kb) Multiome HiCAR | 770 | |
| chr14:23,631,551–23,632,458 | 321.6 kb | Distal (>10kb) Multiome HiCAR | 545 | |
| chr14:23,910,478–23,911,853 | 42.9 kb | Distal (>10kb) Multiome | 310 | |
| chr14:23,953,479–23,954,293 | 43 bp | At TSS Multiome | 897 | |
| chr14:23,988,469–23,989,172 | 35.0 kb | Distal (>10kb) Multiome | 439 | |
| chr14:24,036,218–24,036,993 | 82.8 kb | Distal (>10kb) Multiome | 627 | |
| chr14:24,051,239–24,052,875 | 98.2 kb | Distal (>10kb) Multiome | 821 | |
| chr14:24,080,914–24,082,038 | 127.7 kb | Distal (>10kb) Multiome | 706 | |
| chr14:24,093,491–24,095,115 | 140.5 kb | Distal (>10kb) Multiome | 990 | |
| chr14:24,113,681–24,115,917 | 161.2 kb | Distal (>10kb) Multiome | 1166 | |
| chr14:24,135,549–24,136,884 | 182.3 kb | Distal (>10kb) Multiome | 778 | |
| chr14:24,140,526–24,142,331 | 187.9 kb | Distal (>10kb) Multiome | 1034 | |
| chr14:24,146,204–24,148,108 | 193.0 kb | Distal (>10kb) Multiome | 918 | |
| chr14:24,160,877–24,161,762 | 207.5 kb | Distal (>10kb) Multiome | 970 | |
| chr14:24,171,489–24,172,698 | 218.1 kb | Distal (>10kb) Multiome | 365 | |
| chr14:24,188,229–24,189,111 | 235.0 kb | Distal (>10kb) Multiome | 1074 | |
| chr14:24,195,072–24,196,365 | 241.8 kb | Distal (>10kb) Multiome | 1059 | |
| chr14:24,212,871–24,213,884 | 259.6 kb | Distal (>10kb) Multiome | 1036 | |
| chr14:24,215,523–24,216,241 | 262.2 kb | Distal (>10kb) Multiome | 955 | |
| chr14:24,231,706–24,233,147 | 278.8 kb | Distal (>10kb) Multiome | 1027 | |
| chr14:24,241,845–24,243,572 | 288.8 kb | Distal (>10kb) Multiome | 1077 |
Genomic view of the DHRS4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.