Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be involved in regulation of retinoic acid receptor signaling pathway and retinoid metabolic process. Predicted to act upstream of or within several processes, including heart morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in endoplasmic reticulum membrane and photoreceptor outer segment membrane. Predicted to be active in lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DHRS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHRS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHRS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:12,433,370–12,434,013 | 185.4 kb | Distal (>10kb) Multiome HiCAR | 607 | |
| chr1:12,510,733–12,511,367 | 108.2 kb | Distal (>10kb) Multiome | 319 | |
| chr1:12,594,875–12,596,425 | 23.7 kb | Distal (>10kb) Multiome | 573 | |
| chr1:12,603,861–12,604,867 | 14.7 kb | Distal (>10kb) Multiome | 769 | |
| chr1:12,615,750–12,617,346 | 2.8 kb | Proximal (<10kb) Multiome | 819 | |
| chr1:12,617,934–12,618,892 | 876 bp | At TSS Multiome | 768 | |
| chr1:12,618,995–12,620,143 | 867 bp | At TSS Multiome | 779 |
Genomic view of the DHRS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.