This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for DHRS12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHRS12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHRS12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:51,451,249–51,454,202 | 352.4 kb | Distal (>10kb) Multiome HiCAR | 1037 | |
| chr13:51,583,370–51,585,461 | 220.0 kb | Distal (>10kb) Multiome | 1008 | |
| chr13:51,795,081–51,795,749 | 8.7 kb | Proximal (<10kb) Multiome | 50 | |
| chr13:51,797,590–51,797,999 | 6.2 kb | Proximal (<10kb) | 169 | |
| chr13:51,803,129–51,804,466 | 182 bp | At TSS Multiome | 844 | |
| chr13:51,997,545–51,998,310 | 193.9 kb | Distal (>10kb) Multiome | 461 | |
| chr13:52,011,124–52,012,698 | 208.0 kb | Distal (>10kb) Multiome | 960 |
Genomic view of the DHRS12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.