Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity; and estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Involved in steroid biosynthetic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DHRS11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHRS11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHRS11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:36,482,565–36,483,505 | 108.8 kb | Distal (>10kb) Multiome | 734 | |
| chr17:36,486,066–36,487,171 | 105.2 kb | Distal (>10kb) Multiome | 719 | |
| chr17:36,534,162–36,535,815 | 56.9 kb | Distal (>10kb) Multiome | 1014 | |
| chr17:36,544,068–36,546,005 | 46.4 kb | Distal (>10kb) Multiome | 968 | |
| chr17:36,591,430–36,592,642 | 59 bp | At TSS Multiome | 585 | |
| chr17:36,600,997–36,602,715 | 9.7 kb | Proximal (<10kb) Multiome | 823 | |
| chr17:36,657,825–36,658,420 | 66.2 kb | Distal (>10kb) Multiome | 220 | |
| chr17:36,722,258–36,722,869 | 130.6 kb | Distal (>10kb) Multiome | 428 | |
| chr17:36,808,179–36,808,595 | 216.5 kb | Distal (>10kb) Multiome | 138 |
Genomic view of the DHRS11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.