The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for DHDDS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHDDS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHDDS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:26,161,287–26,162,232 | 270.5 kb | Distal (>10kb) Multiome | 564 | |
| chr1:26,164,134–26,165,044 | 267.8 kb | Distal (>10kb) Multiome | 500 | |
| chr1:26,169,358–26,170,373 | 262.5 kb | Distal (>10kb) Multiome | 969 | |
| chr1:26,177,126–26,177,750 | 254.9 kb | Distal (>10kb) Multiome | 363 | |
| chr1:26,200,994–26,201,612 | 231.1 kb | Distal (>10kb) Multiome | 369 | |
| chr1:26,225,042–26,225,908 | 206.9 kb | Distal (>10kb) Multiome | 462 | |
| chr1:26,233,613–26,234,924 | 198.2 kb | Distal (>10kb) Multiome | 867 | |
| chr1:26,275,604–26,276,096 | 156.5 kb | Distal (>10kb) Multiome | 373 | |
| chr1:26,279,438–26,280,566 | 152.4 kb | Distal (>10kb) Multiome | 820 | |
| chr1:26,306,331–26,306,935 | 125.6 kb | Distal (>10kb) Multiome | 563 | |
| chr1:26,335,993–26,337,256 | 95.8 kb | Distal (>10kb) Multiome | 655 | |
| chr1:26,360,031–26,360,668 | 72.0 kb | Distal (>10kb) Multiome | 164 | |
| chr1:26,409,125–26,412,949 | 21.8 kb | Distal (>10kb) Multiome | 517 | |
| chr1:26,416,811–26,417,349 | 15.2 kb | Distal (>10kb) Multiome | 290 | |
| chr1:26,418,111–26,419,646 | 13.2 kb | Distal (>10kb) Multiome | 189 | |
| chr1:26,431,868–26,432,811 | 107 bp | At TSS Multiome | 1083 | |
| chr1:26,471,339–26,473,364 | 40.6 kb | Distal (>10kb) Multiome | 992 | |
| chr1:26,500,060–26,501,704 | 68.0 kb | Distal (>10kb) Multiome | 1028 | |
| chr1:26,529,200–26,531,855 | 99.1 kb | Distal (>10kb) Multiome | 703 | |
| chr1:26,620,089–26,621,718 | 188.4 kb | Distal (>10kb) Multiome | 1174 | |
| chr1:26,692,203–26,693,499 | 260.1 kb | Distal (>10kb) Multiome | 974 | |
| chr1:26,695,271–26,696,473 | 263.4 kb | Distal (>10kb) Multiome | 1053 | |
| chr1:26,723,135–26,723,892 | 291.2 kb | Distal (>10kb) Multiome | 671 |
Genomic view of the DHDDS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.