The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for DGKZ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DGKZ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DGKZ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:46,120,416–46,122,472 | 225.9 kb | Distal (>10kb) Multiome | 758 | |
| chr11:46,238,964–46,239,736 | 108.1 kb | Distal (>10kb) Multiome | 559 | |
| chr11:46,242,857–46,244,010 | 104.0 kb | Distal (>10kb) Multiome HiCAR | 900 | |
| chr11:46,277,351–46,278,874 | 68.9 kb | Distal (>10kb) Multiome | 343 | |
| chr11:46,294,934–46,295,998 | 51.9 kb | Distal (>10kb) Multiome | 533 | |
| chr11:46,296,747–46,297,460 | 50.3 kb | Distal (>10kb) Multiome | 415 | |
| chr11:46,332,531–46,332,967 | at TSS | At TSS | 181 | |
| chr11:46,333,106–46,333,554 | 202 bp | At TSS | 153 | |
| chr11:46,338,698–46,339,679 | 8.2 kb | Proximal (<10kb) Multiome | 393 | |
| chr11:46,345,179–46,345,519 | 1.9 kb | Proximal (<10kb) | 180 | |
| chr11:46,346,987–46,348,092 | 82 bp | At TSS Multiome | 586 | |
| chr11:46,352,002–46,352,557 | 4.9 kb | Proximal (<10kb) Multiome | 306 | |
| chr11:46,367,493–46,367,978 | at TSS | At TSS | 250 | |
| chr11:46,369,520–46,369,901 | 1.9 kb | Proximal (<10kb) | 309 | |
| chr11:46,379,120–46,383,444 | 32.2 kb | Distal (>10kb) Multiome | 930 | |
| chr11:46,388,459–46,390,750 | 41.4 kb | Distal (>10kb) Multiome | 593 | |
| chr11:46,391,139–46,393,221 | 45.3 kb | Distal (>10kb) Multiome | 965 | |
| chr11:46,407,311–46,408,466 | 60.4 kb | Distal (>10kb) Multiome | 157 | |
| chr11:46,554,280–46,555,184 | 207.3 kb | Distal (>10kb) Multiome | 531 | |
| chr11:46,593,562–46,594,345 | 246.5 kb | Distal (>10kb) Multiome | 845 | |
| chr11:46,616,855–46,618,064 | 269.8 kb | Distal (>10kb) Multiome | 823 |
Genomic view of the DGKZ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.