The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for DGKA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DGKA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DGKA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:55,645,990–55,646,787 | 284.8 kb | Distal (>10kb) Multiome | 520 | |
| chr12:55,681,171–55,682,136 | 249.6 kb | Distal (>10kb) Multiome | 647 | |
| chr12:55,707,276–55,708,500 | 223.1 kb | Distal (>10kb) Multiome | 372 | |
| chr12:55,715,733–55,716,775 | 214.9 kb | Distal (>10kb) Multiome | 929 | |
| chr12:55,727,952–55,730,453 | 201.8 kb | Distal (>10kb) Multiome | 895 | |
| chr12:55,736,969–55,737,781 | 193.9 kb | Distal (>10kb) Multiome | 496 | |
| chr12:55,737,830–55,739,085 | 192.6 kb | Distal (>10kb) Multiome | 475 | |
| chr12:55,742,540–55,744,252 | 188.0 kb | Distal (>10kb) Multiome | 631 | |
| chr12:55,745,091–55,746,361 | 185.4 kb | Distal (>10kb) Multiome | 299 | |
| chr12:55,817,254–55,818,558 | 113.3 kb | Distal (>10kb) Multiome | 749 | |
| chr12:55,829,008–55,831,505 | 101.5 kb | Distal (>10kb) Multiome HiCAR | 921 | |
| chr12:55,926,651–55,928,471 | 3.1 kb | Proximal (<10kb) Multiome | 993 | |
| chr12:55,930,805–55,930,970 | 3.5 kb | Proximal (<10kb) | 254 | |
| chr12:55,931,904–55,932,439 | 949 bp | At TSS Multiome | 279 | |
| chr12:55,940,073–55,940,746 | 9.2 kb | Proximal (<10kb) Multiome | 478 | |
| chr12:55,966,006–55,967,470 | 35.6 kb | Distal (>10kb) Multiome | 615 | |
| chr12:55,973,347–55,974,716 | 42.7 kb | Distal (>10kb) Multiome | 966 | |
| chr12:55,996,814–55,997,861 | 66.0 kb | Distal (>10kb) Multiome | 680 | |
| chr12:56,006,888–56,008,461 | 76.5 kb | Distal (>10kb) Multiome | 745 | |
| chr12:56,020,644–56,021,511 | 89.8 kb | Distal (>10kb) Multiome | 364 | |
| chr12:56,041,220–56,042,537 | 110.6 kb | Distal (>10kb) Multiome | 1035 | |
| chr12:56,078,964–56,081,015 | 148.9 kb | Distal (>10kb) Multiome | 1032 | |
| chr12:56,103,918–56,105,302 | 173.2 kb | Distal (>10kb) Multiome | 977 | |
| chr12:56,115,844–56,117,060 | 185.3 kb | Distal (>10kb) Multiome | 958 | |
| chr12:56,117,641–56,119,301 | 187.0 kb | Distal (>10kb) Multiome | 1052 | |
| chr12:56,126,181–56,126,640 | 195.1 kb | Distal (>10kb) Multiome | 671 | |
| chr12:56,127,552–56,129,104 | 196.9 kb | Distal (>10kb) Multiome | 800 | |
| chr12:56,151,724–56,153,003 | 221.3 kb | Distal (>10kb) Multiome | 830 | |
| chr12:56,157,307–56,159,499 | 227.0 kb | Distal (>10kb) Multiome | 1008 | |
| chr12:56,188,836–56,190,865 | 259.2 kb | Distal (>10kb) Multiome | 954 | |
| chr12:56,221,094–56,222,691 | 290.8 kb | Distal (>10kb) Multiome | 884 | |
| chr12:56,223,843–56,224,800 | 293.1 kb | Distal (>10kb) Multiome | 765 |
Genomic view of the DGKA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.