This gene, the result of a duplication at this locus, is one of two functional genes encoding nearly identical proteins that have similar expression patterns. The product of this gene is a protein that shares homology with the Drosophila gonadal protein, expressed in gonadal tissues and germ cells, and with the human laminin gamma-1 chain that functions in cell attachment and migration. This gene is located in a region of chromosome 22 implicated in the DiGeorge syndrome, one facet of a broader collection of anomalies referred to as the CATCH 22 syndrome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DGCR6L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DGCR6L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DGCR6L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:20,020,662–20,021,745 | 299.0 kb | Distal (>10kb) Multiome | 718 | |
| chr22:20,079,663–20,080,743 | 239.9 kb | Distal (>10kb) Multiome | 994 | |
| chr22:20,116,628–20,118,048 | 202.7 kb | Distal (>10kb) Multiome | 999 | |
| chr22:20,130,806–20,131,896 | 188.8 kb | Distal (>10kb) Multiome | 525 | |
| chr22:20,203,393–20,204,086 | 116.2 kb | Distal (>10kb) Multiome | 292 | |
| chr22:20,243,636–20,244,300 | 76.0 kb | Distal (>10kb) Multiome | 251 | |
| chr22:20,267,373–20,268,700 | 51.6 kb | Distal (>10kb) Multiome | 449 | |
| chr22:20,298,366–20,300,076 | 20.8 kb | Distal (>10kb) Multiome | 538 | |
| chr22:20,319,527–20,320,815 | 92 bp | At TSS Multiome | 805 | |
| chr22:20,393,744–20,394,682 | 74.1 kb | Distal (>10kb) Multiome | 854 | |
| chr22:20,418,190–20,418,662 | 98.4 kb | Distal (>10kb) Multiome | 594 | |
| chr22:20,431,567–20,432,135 | 111.8 kb | Distal (>10kb) Multiome | 135 | |
| chr22:20,437,361–20,438,451 | 117.9 kb | Distal (>10kb) Multiome | 393 | |
| chr22:20,495,029–20,496,932 | 175.8 kb | Distal (>10kb) Multiome | 1018 | |
| chr22:20,507,376–20,507,935 | 187.6 kb | Distal (>10kb) Multiome | 894 | |
| chr22:20,606,015–20,606,540 | 286.4 kb | Distal (>10kb) Multiome | 411 |
Genomic view of the DGCR6L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.